Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene 223 [antikvár]

Zbl. Bakt. Hyg., I. Abt. Orig. A 223, 1-14 (1973) Aus der Bundesforschungsanstalt für Viruskrankheiten der Tiere in Tübingen Statistische Erhebungen über Impfschäden nach der Maul- und-Klauenseuche-Schutzimpfung im Jahr 1970 Statistical Evaluation of Allergie Reactions following Vaccinations against Foot-and-Mouth Disease in 1970 R. J. Lorenz und O. C. Straub Mit 1 Abbildung • Eingegangen am 10. Mai 1972 Abstract From 7.97 millions of catrie vaccinated 1970 for FMD in the Federal Republic of Germany 576 allergic reactions (= 0.0072»/o) and 330 abortions (= 0.0041''/o) were reported. 290 of the allergic reactions (= O.OOSS'/o) were of the immediate and 286 (= 0.0036°/o) of the delayed type. The letality rate was 47% in cases of the immediate and 42Vo in the ones with delayed type reaction. The incidence rate following vaccinations for FMD has been found to be relatively stable over three periods of vaccinations (1967/68, 1968/69, 1970) with an average of 0.012»/o (allergic reacrions: O.OOS'/o, aborrions: 0.004Vo). This low rate offers therefore no argument against annual vaccinations. Five different vaccines were used: Bayer, Behring, Wellcome, Bellon, and Iffa. The first three are cell culture vaccines, the other ones Frenkel-vaccines. The variation of reaction rates among the vaccines ranged from O.OOilVo to 0.0094''/o for allergic reactions, and from 0.0009"/o to 0.0122"/o for abortions. In 18 animals an immediate type allergic reaction and an abortion occurred concurrently; 67 animals showed a delayed type reaction connected with an abortion. These figures are 1500 and 5 600 times higher than the expected rate if allergic reactions and abornons were independendy and randomly distributed throughout the populadon. It could therefore be concluded that the predispositions to allergic reactions and abortions are not independent. The predisposition also depends on the number of preceding vaccinations: Whereas allergic reactions following the second vaccinations were less frequent than following the first one they showed a distinct increase after the third and the fourth vaccination (Fig. 1 and Table 4). The risk of an abortion generally increases with the number of preceding vaccinations. There are reasons to suspect that the kind of vaccine used at the preceding vaccinations is of considerable influence. Animals which previously received a Frenkel-vaccine, are more susceptible to an allergic reaction or to an abortion than animals prevaccinated with a cell culture vaccine. This susceptibility seems to increase in those animals repeatedly vaccinated with Frenkel-vaccines. It is recommended that vaccinations of animals in the later stages of pregnancy should be postponed.