Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene 159 [antikvár]

Zbl. Bakt. Hyg., I. Abt. Orig. B 159, 1-9 (1974) Aus dem Hygiene-Institut der Universität Mainz (Direktor: Prof. Dr. J.Borneff) Untersuchungen über den Einfluß verschiedener Virusinfektionen auf die 3,4-Benzpyren-Kanzerogenese Studies about the Influence of Different Viruses on the Benzo(a)pyrene Carcinogenesis E.H.Pfeiffer und Z.Graf Mit 3 Abbildungen Abstract Reviewing the applicable literature, we found that the influence of various non-tumor formating viruses upon the benzo(a)pyrene carcinogenesis is not well known. Therefore we examined the effect of the vaccinia-, poliomyelitis- and echovirus infection upon the development of tumors induced by benzo(a)pyrene. 10^g, 50|ag or 100^g benzo(a)pyrene were injected once to female mice subcutaneously. 12 days later the mi.ce were immunised by application of vaccinia, poliomyelitis virus type II or echovirus type 11. The test revealed the following: 1. The tumor development by 10n% benzo(a)pyrene will be increased by a vaccinia-infec-tion, while it decreases slightly by a polio- or echovirus-infection. The differences in impact are not significant. 2. After the application of 50^g benzo(a)pyrene the tumor rates were reduced by all three virus types. 3. By 100//g benzo(a)pyrene the tumor development will be reduced significantly by immunisation of vaccinia-, polio- or echoviruses, i.e. the higher the dosis of chemical carcinogens the more obvious is the protecdon by immunisation. 4. The average tumor induction time is not affected by these virus infections, in general. 5. The dosis-effect-relations of benzo(a)pyrene will be modified by a vaccinia-infection, whereas the polio- or echovirus-infection slightly changes it negatively. Conclusions to the human cancerogenesis are not yet possible. Zusammenfassung Bei Durchsicht der Literatur stellten wir fest, daß die Wirkung verschiedener nicht-tumorauslösender Virusinfektionen auf die 3,4-Benzpyren-Kanzerogenese unklar ist. Daher untersuchten wir den Effekt einer Vaccinia-, Poliomyelitis- und LCHO-Vireninfektion auf die Entstehung 3,4-Benzpyren-induzierter Tumoren. Weiblichen NMRI-Mäusen wurden jeweils einmal 10, 50 bzw. 100//g Benzpyren s.c. appliziert. 12 Tage später immunisierten wir diese Mäuse durch einmalige intraperitoneale Verabreichung des Vaccinia- bzw. Poliovirus Typ II oder ECHO-Virus Typ 11. 1 Zbl. Bakt. Hyg., I. Abt. Orig. B 159.