The Control of Poliomyelitis by Live Poliovirus Vaccine [antikvár]

PREFACE Live attenuated poliovirus vaccine as developed by A. B. Sabin has "been applied on a wide scale in the USSR, where nearly 90 millión subjects were fed the vaccine in the years 1959 and 1960. In connection with the mass vaccinations extensive studies were carried out by two groups of Soviet workers, the one led by M. P. Chumakov, the other by A. A. Smokodintsev. The highly valuable results of the studies were summarized at the 4th Scientific Conference and International Symposium onLive Poliovirus Vaccine, Moscow, May, 1960. Since then the studies have been continued and the results obtained by Chumakov up to January 1, 1961, are presented in this issue. In July, 1959, a severe epidemic of poliomyelitis broke out in Hungary, although a high percentage of the child population had received Salk vaccine in the period 1957--1959. In face of the epidemic situation the Microbiological Committee of the Scientific Council of the Hungárián Ministry of Health on the basis of the favourable experience obtained in the USSR proposed in July, 1959, wide-scale application of the live attenuated vaccine. At the 2nd Congress of the Hungárián Association of Microbiologists, September, 1959, Chumakov reported on the vaccinations carried out in the USSR, and offered 100 000 doses of trivalent vaccine. In addition, he assured to supply Hungary with 2y2 millión doses of live vaccine to immunize the child-population of the whole country. Vacoination was begun in November, 1959, in Győr-Sopron county, where the trivalent vaccine was administered. One month later the campaign was extended to the whole country, with monovalent vaccines, administered in the ordertype l,type3 andtype2.Toevaluatetheeffectiveness of the vaccinations, epidemiological, virological, serological and clinical investigations were organized. The Epidemiological Department of the 7