Effects of intraventricular administration of cholecystokinin octapeptide sulfate ester and unsulfated cholecystokinin octapeptide on active avoidance and conditioned feeding behaviour of rats [antikvár]

Acta Physiologica Acadcmiae Scientiarum Hungaricae, Tomus 58 (1), pp. 39-45 (1981) EFFECTS OF INTRAYENTRICULAR ADMINISTRATION OF CHOLECYSTOKININ OCTAPEPTIDE SULFATE ESTER AND UNSULFATED CHOLECYSTOKININ OCTAPEPTIDE ON ACTIVE AVOIDANCE AND CONDITIONED FEEDING BEHAVIOUR OF RATS By M. Fekete, A. Szabó, M. Balázs, B. Penke* and G. Telegdy DEPARTMENT OF PATHOPHYSIOLOGY AND -DEPARTMENT OF MEDICAL CHEMISTRY, UNIVERSITY MEDICAL SCHOOL, SZEGED (Received February 3 9, 1981) The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE) and unsulfated cholecystokinin (CCK-8-NS) were studied following intraventricular administration on active avoidance and conditioned feeding behaviour of rats. In the CCK-8-NS and CCK-8-SE treated animals the acquisition of active avoidance and conditioned feeding behaviour were considerably impaired compared to the control; furthermore, these peptides caused a facilitated extinction of active avoidance and conditioned feeding behaviour. The data su^gest that cholecystokinin octapeptide is capable of modifying the fear and hunger motivated behaviours of rats. Several peptides have been identified in the gastrointestinal endocrine cells and central or peripheral nervous system [14, 17]. One of these was cholecystokinin (CCK) isolated from different brain areas of several species [1, 2, 3, 12, 13, 15, 16, 20, 22, 23, 24, 25, 28, 30, 31]. The physiological role of CCK in the brain is still obscure. Somé authors have suggested that CCK is a satiety factor [10, 19, 26], although these findings have not been universally confirmed [4, 11, 27, 29]. Zetler [33, 34] found antinociceptive effects, palpebral ptosis and sedation, as well as prolonged hexobarbital sleeping time following CCK octapeptide injection in mice. In our earlier work it was demonstrated that cholecystokinin octapeptide sulfate ester (CCK-8-SE) and its unsulfated form (CCK-8-NS), when given intraperitoneally, impaired the acquisition and facilitated the extinction of active avoidance and conditioned feeding behaviour [5, 61 while the latency of passive avoidance behaviour was increased [7]. In these experiments the peripheral effects of cholecystokinin octapeptide 011 increased pancreatic secretion, causing discomfort to the animal, could not be ruled out, which might have affected the motor activity. In the present investigation the effects of CCK-8-NS and CCK-8-SE were studied following intraventricular injection on the active avoidance and conditioned feeding behaviour of rats. Acta Physiologica Academiac Scientiarum Hungaricae 58, 1981