Acta Medica 1964 [antikvár]

INFARCTOID CARDIAC LESIONS INDUCED BYDIETETIC FACTORS IN THE DOGByJ. Sós, T. Gáti, T. Kemény and J. Rigówith the technical assistance of Maria Schnell, Margit Jóna and Ilona Szabóinstitute of pathophysiology (director: j. sós). university medical school, budapest(Received December 6, 1962)Infarctoid cardiac lesions have been observed to arise in four out of five dogsfed a cardiopathogenic diet. In one dog the ECG showed typical cardiac infarction,in another a myocardial lesion, while in the fourth and fifth animals the ECG wasnormal. The cardiopathogenic diet reduced the myocardial potassium and magnesiumcontents to about the lowest normal values. Sclerosis of the aorta was establishedboth histologically and chemically in all the animals. The findings underline the signif-icance of myocardial mineral metabolism in infarctoid cardiac lesions and infarction.In previous papers [15,16] data were presented on infarctoid cardiopathyinduced by dietetic factors in rats. The condition killed the majority of theanimals in about six weeks. Histology revealed myocardial degenerativefoci, infiltration, occasional necrosis, and fibrosis resulting from previousmicronecroses. The myocardial potassium and magnesium contents fellbelow, and the sodium content rose above, normal [12].The cardiac lesion was induced in two ways. Blood pressure was raisedand coronary circulation impaired by producing atheromatosis by hyper-vitaminosis D2 and cholesterol feeding, or, else, in the diet the amount ofsodium and calcium was increased and potassium and magnesium reduced toupset the mineral balance in the myocardium.The aim of the present study was to induce infarctoid cardiopathy bymeans similar to the above in animal species other than the rat. Di Luzioet al. [2] and Hartroft et al. [3] reported that on feeding cholesterol andbutter to dogs treated with thiouracil there developed aortic sclerosis butno cardiac infarction, and in the course of their experiments extending overa full year they observed but a single case of thrombosis, and that was in thesuperior mesenteric artery. All these have induced us to attempt creatinginfarctoid cardiac lesions by dietary means in dogs.