Acta Medica 1964 [antikvár]

INFARCTOID CARDIAC LESIONS INDUCED BY DIETETIC FACTORS IN THE DOG By J. Sós, T. Gáti, T. Kemény and J. Rigó with the technical assistance of Maria Schnell, Margit Jóna and Ilona Szabó institute of pathophysiology (director: j. sós). university medical school, budapest (Received December 6, 1962) Infarctoid cardiac lesions have been observed to arise in four out of five dogs fed a cardiopathogenic diet. In one dog the ECG showed typical cardiac infarction, in another a myocardial lesion, while in the fourth and fifth animals the ECG was normal. The cardiopathogenic diet reduced the myocardial potassium and magnesium contents to about the lowest normal values. Sclerosis of the aorta was established both histologically and chemically in all the animals. The findings underline the signif- icance of myocardial mineral metabolism in infarctoid cardiac lesions and infarction. In previous papers [15,16] data were presented on infarctoid cardiopathy induced by dietetic factors in rats. The condition killed the majority of the animals in about six weeks. Histology revealed myocardial degenerative foci, infiltration, occasional necrosis, and fibrosis resulting from previous micronecroses. The myocardial potassium and magnesium contents fell below, and the sodium content rose above, normal [12]. The cardiac lesion was induced in two ways. Blood pressure was raised and coronary circulation impaired by producing atheromatosis by hyper- vitaminosis D2 and cholesterol feeding, or, else, in the diet the amount of sodium and calcium was increased and potassium and magnesium reduced to upset the mineral balance in the myocardium. The aim of the present study was to induce infarctoid cardiopathy by means similar to the above in animal species other than the rat. Di Luzio et al. [2] and Hartroft et al. [3] reported that on feeding cholesterol and butter to dogs treated with thiouracil there developed aortic sclerosis but no cardiac infarction, and in the course of their experiments extending over a full year they observed but a single case of thrombosis, and that was in the superior mesenteric artery. All these have induced us to attempt creating infarctoid cardiac lesions by dietary means in dogs.